Pulmonary Hypertension in the Newborn GTP-Cyclohydrolase 1-Deficient Mouse

Tetrahydrobiopterin (BH4) is a regulator of endothelial nitric oxide synthase (eNOS) activity. Deficient levels result in eNOS uncoupling with a shift from nitric oxide (NO) to superoxide generation. The hph-1 mutant mouse has deficient GTP-cyclohydrolase 1 (GTPCH1) activity resulting in low BH4 tis...

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Bibliografske podrobnosti
izdano v:Free Radic Biol Med
Main Authors: Belik, Jaques, McIntyre, Brendan A.S., Enomoto, Masahiro, Pan, Jingyi, Grasemann, Hartmut, Vasquez-Vivar, Jeannette
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050525/
https://ncbi.nlm.nih.gov/pubmed/21982896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.09.012
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