T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice

The etiology and pathophysiology underlying opioid tolerance and dependence are still unknown. Because mu opioid receptor (MOR) plays an essential role in opioid action, many vulnerability-related studies have focused on single nucleotide polymorphisms of MOR, particularly on A118G. In this study, w...

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Publicat a:J Neurosci
Autors principals: Wang, Xiao-Fei, Barbier, Elisabeth, Chiu, Yi-Ting, He, Yi, Zhan, Jia, Bi, Guo-Hua, Zhang, Hai-Ying, Feng, Bo, Liu-Chen, Lee-Yuan, Wang, Jia Bei, Xi, Zheng-Xiong
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050331/
https://ncbi.nlm.nih.gov/pubmed/27707973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0603-16.2016
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