Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability

Regulation of osteoblast and osteocyte viability is essential for bone homeostasis. Smad4, a major transducer of bone morphogenetic protein and transforming growth factor-β signaling pathways, regulates apoptosis in various cell types through a mitochondrial pathway. However, it remains poorly under...

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Vydáno v:Exp Mol Med
Hlavní autoři: Moon, Young Jae, Yun, Chi-Young, Choi, Hwajung, Ka, Sun-O, Kim, Jung Ryul, Park, Byung-Hyun, Cho, Eui-Sic
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050296/
https://ncbi.nlm.nih.gov/pubmed/27585718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2016.75
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