(13)C Metabolic Flux Analysis for Systematic Metabolic Engineering of S. cerevisiae for Overproduction of Fatty Acids

Efficient redirection of microbial metabolism into the abundant production of desired bioproducts remains non-trivial. Here, we used flux-based modeling approaches to improve yields of fatty acids in Saccharomyces cerevisiae. We combined (13)C labeling data with comprehensive genome-scale models to...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Ghosh, Amit, Ando, David, Gin, Jennifer, Runguphan, Weerawat, Denby, Charles, Wang, George, Baidoo, Edward E. K., Shymansky, Chris, Keasling, Jay D., García Martín, Héctor
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050205/
https://ncbi.nlm.nih.gov/pubmed/27761435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2016.00076
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