Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment

The ecto-5'-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Antonioli, Luca, Blandizzi, Corrado, Malavasi, Fabio, Ferrari, Davide, Haskó, György
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
Subjects:
Editorial
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048762/
https://ncbi.nlm.nih.gov/pubmed/27757316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1216292
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