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Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggests Limited Functional Role
Dimer formation is believed to have a substantial impact on regulating K-Ras function. However, the evidence for dimerization and the molecular details of the process are scant. In this study, we characterize a K-Ras pseudo-C(2)-symmetric dimerization interface involving the effector interacting β2-...
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| Publicado en: | J Phys Chem B |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5048749/ https://ncbi.nlm.nih.gov/pubmed/27072779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b02403 |
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