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The BRAF(V600E) inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells
Vertical growth phase (VGP) melanoma is frequently metastatic, a process mediated by changes in gene expression, which are directed by signal transduction pathways in the tumor cells. A prominent signaling pathway is the Ras-Raf-Mek-Erk MAPK pathway, which increases expression of genes that promote...
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| Publié dans: | Matrix Biol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5048745/ https://ncbi.nlm.nih.gov/pubmed/25989506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2015.05.007 |
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