PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF(WT) melanoma cells

BRAF(V600E/K) is a frequent mutationally active tumor-specific kinase in melanomas that is currently targeted for therapy by the specific inhibitor PLX4032. Our studies with melanoma tumor cells that are BRAF(V600E/K) and BRAF(WT) showed that, paradoxically, while PLX4032 inhibited ERK1/2 in the hig...

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Bibliographic Details
Main Authors: Halaban, Ruth, Zhang, Wengeng, Bacchiocchi, Antonella, Cheng, Elaine, Parisi, Fabio, Ariyan, Stephan, Krauthammer, Michael, McCusker, James P, Kluger, Yuval, Sznol, Mario
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2010
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848976/
https://ncbi.nlm.nih.gov/pubmed/20149136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2010.00685.x
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