A20 suppresses canonical Smad-dependent fibroblast activation: novel function for an endogenous inflammatory modulator

BACKGROUND: The ubiquitin-editing cytosolic enzyme A20, the major negative regulator of toll-like receptor (TLR)-mediated cellular inflammatory responses, has tight genetic linkage with systemic sclerosis (SSc). Because recent studies implicate endogenous ligand-driven TLR signaling in SSc pathogene...

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Bibliografiska uppgifter
I publikationen:Arthritis Res Ther
Huvudupphovsmän: Bhattacharyya, Swati, Wang, Wenxia, Graham, Lauren Van Duyn, Varga, John
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048449/
https://ncbi.nlm.nih.gov/pubmed/27716397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1118-7
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