The Transcriptional Cofactor Nab2 Is Induced by TGF-β and Suppresses Fibroblast Activation: Physiological Roles and Impaired Expression in Scleroderma

By stimulating collagen synthesis and myofibroblasts differentiation, transforming growth factor-β (TGF- β) plays a pivotal role in tissue repair and fibrosis. The early growth response-1 (Egr-1) transcription factor mediates profibrotic TGF-β responses, and its expression is elevated in biopsies fr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bhattacharyya, Swati, Wei, Jun, Melichian, Denisa S., Milbrandt, Jeffrey, Takehara, Kazuhiko, Varga, John
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2009
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768752/
https://ncbi.nlm.nih.gov/pubmed/19888474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007620
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