Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

Ligands of peroxisome proliferator-activated receptor-γ (PPAR-γ) abrogate the stimulation of collagen gene transcription induced by transforming growth factor-beta (TGF-β). Here, we delineate the mechanisms underlying this important novel physiological function for PPAR-γ in connective tissue homeos...

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Detalhes bibliográficos
Main Authors: Ghosh, Asish K., Bhattacharyya, Swati, Wei, Jun, Kim, Suyeon, Barak, Yaacov, Mori, Yasuji, Varga, John
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735362/
https://ncbi.nlm.nih.gov/pubmed/19395477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-128736
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