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A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system

The ubiquitin-proteasome system (UPS) is a selective protein degradation system that plays a critical role in many essential biological processes by regulating the existence of various cellular proteins. The target proteins of UPS are recognized and tagged with polyubiquitin chains by E3 ubiquitin l...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kuchimaru, Takahiro, Suka, Tomoya, Hirota, Keisuke, Kadonosono, Tetsuya, Kizaka-Kondoh, Shinae
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048432/
https://ncbi.nlm.nih.gov/pubmed/27698477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34311
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