The variances of Sp1 and NF-κB elements correlate with the greater capacity of Chinese HIV-1 B′-LTR for driving gene expression

The 5′ end of HIV-1 long terminal repeat (LTR) serves as a promoter that plays an essential role in driving viral gene transcription. Manipulation of HIV-1 LTR provides a potential therapeutic strategy for suppressing viral gene expression or excising integrated provirus. Subtype-specific genetic di...

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Sparad:
Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Qu, Di, Li, Chuan, Sang, Feng, Li, Qiang, Jiang, Zhi-Qiang, Xu, Li-Ran, Guo, Hui-Jun, Zhang, Chiyu, Wang, Jian-Hua
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048295/
https://ncbi.nlm.nih.gov/pubmed/27698388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34532
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