A knockin mouse model for human ATP4a(R703C) mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

By whole exome sequencing, we recently identified a missense mutation (p.R703C) in the human ATP4a gene, which encodes the proton pump responsible for gastric acidification. This mutation causes an aggressive familial type I gastric neuroendocrine tumor in homozygous individuals. Affected individual...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Dis Model Mech
Autores principales: Calvete, Oriol, Varro, Andrea, Pritchard, D. Mark, Barroso, Alicia, Oteo, Marta, Morcillo, Miguel Ángel, Vargiu, Pierfrancesco, Dodd, Steven, Garcia, Miriam, Reyes, José, Ortega, Sagrario, Benitez, Javier
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047686/
https://ncbi.nlm.nih.gov/pubmed/27491072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.025890
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares