Tumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis

The relevance of Corticotropin Releasing Hormone (CRH)-system in human malignancies is a question of growing interest. Here we investigated hypermethylation and epigenetic silencing of the CRH-Binding Protein (CRHBP) gene in clear cell renal cell cancer (ccRCC). Relative methylation of the CRHBP CpG...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tezval, Hossein, Dubrowinskaja, Natalia, Peters, Inga, Reese, Christel, Serth, Katrin, Atschekzei, Faranaz, Hennenlotter, Jörg, Stenzl, Arnulf, Kuczyk, Markus A., Serth, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047469/
https://ncbi.nlm.nih.gov/pubmed/27695045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163873
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