Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation

Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a leading asexual blood stage vaccine candidate for malaria. In preparation for clinical trials, three Diversity Covering (DiCo) PfAMA1 ectodomain proteins, designed to overcome the intrinsic polymorphism that is present in PfAMA1, were pro...

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Publicado en:PLoS One
Autores principales: Faber, Bart W., Hellwig, Stephan, Houard, Sophie, Havelange, Nicolas, Drossard, Jürgen, Mertens, Hubert, Croon, Alexander, Kastilan, Robin, Byrne, Richard, van der Werff, Nicole, van der Eijk, Marjolein, Thomas, Alan W., Kocken, Clemens H. M., Remarque, Edmond J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047445/
https://ncbi.nlm.nih.gov/pubmed/27695087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164053
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