Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation

Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a leading asexual blood stage vaccine candidate for malaria. In preparation for clinical trials, three Diversity Covering (DiCo) PfAMA1 ectodomain proteins, designed to overcome the intrinsic polymorphism that is present in PfAMA1, were pro...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Faber, Bart W., Hellwig, Stephan, Houard, Sophie, Havelange, Nicolas, Drossard, Jürgen, Mertens, Hubert, Croon, Alexander, Kastilan, Robin, Byrne, Richard, van der Werff, Nicole, van der Eijk, Marjolein, Thomas, Alan W., Kocken, Clemens H. M., Remarque, Edmond J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047445/
https://ncbi.nlm.nih.gov/pubmed/27695087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164053
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