CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice

Narcolepsy with cataplexy is a rare and severe sleep disorder caused by the destruction of orexinergic neurons in the lateral hypothalamus. The genetic and environmental factors associated with narcolepsy, together with serologic data, collectively point to an autoimmune origin. The current animal m...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bernard-Valnet, Raphaël, Yshii, Lidia, Quériault, Clémence, Nguyen, Xuan-Hung, Arthaud, Sébastien, Rodrigues, Magda, Canivet, Astrid, Morel, Anne-Laure, Matthys, Arthur, Bauer, Jan, Pignolet, Béatrice, Dauvilliers, Yves, Peyron, Christelle, Liblau, Roland S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047186/
https://ncbi.nlm.nih.gov/pubmed/27621438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603325113
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