CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice

Narcolepsy with cataplexy is a rare and severe sleep disorder caused by the destruction of orexinergic neurons in the lateral hypothalamus. The genetic and environmental factors associated with narcolepsy, together with serologic data, collectively point to an autoimmune origin. The current animal m...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Bernard-Valnet, Raphaël, Yshii, Lidia, Quériault, Clémence, Nguyen, Xuan-Hung, Arthaud, Sébastien, Rodrigues, Magda, Canivet, Astrid, Morel, Anne-Laure, Matthys, Arthur, Bauer, Jan, Pignolet, Béatrice, Dauvilliers, Yves, Peyron, Christelle, Liblau, Roland S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047186/
https://ncbi.nlm.nih.gov/pubmed/27621438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603325113
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