Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice

Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and in populations with chronic conditions such as renal failure, diabetes, HIV and alcohol abuse. Currently, other than supportive care and antibiotics, there are no treatments for this condition. We developed an in...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Doerflinger, Marcel, Glab, Jason, Nedeva, Christina, Jose, Irvin, Lin, Ann, O’Reilly, Lorraine, Allison, Cody, Pellegrini, Marc, Hotchkiss, Richard S., Puthalakath, Hamsa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046154/
https://ncbi.nlm.nih.gov/pubmed/27694827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34702
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