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Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions
The E6 protein from human papillomavirus (HPV) plays an important role during productive infection and is a potential drug target. We have previously designed a high affinity bivalent protein binder for the E6 protein, a fusion between a helix from the E6 associated protein and PDZØ9, an engineered...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5046105/ https://ncbi.nlm.nih.gov/pubmed/27694853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34269 |
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