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Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions

The E6 protein from human papillomavirus (HPV) plays an important role during productive infection and is a potential drug target. We have previously designed a high affinity bivalent protein binder for the E6 protein, a fusion between a helix from the E6 associated protein and PDZØ9, an engineered...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Karlsson, O. Andreas, Sundell, Gustav N., Andersson, Eva, Ivarsson, Ylva, Jemth, Per
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046105/
https://ncbi.nlm.nih.gov/pubmed/27694853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34269
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