The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells

BACKGROUND: Oxidative stress is implicated in increased vascular permeability associated with metabolic disorders, but the underlying redox mechanism is poorly defined. S-glutathionylation, a stable adduct of glutathione with protein sulfhydryl, is a reversible oxidative modification of protein and...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Han, Jingyan, Weisbrod, Robert M., Shao, Di, Watanabe, Yosuke, Yin, Xiaoyan, Bachschmid, Markus M., Seta, Francesca, Janssen-Heininger, Yvonne M.W., Matsui, Reiko, Zang, Mengwei, Hamburg, Naomi M., Cohen, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045950/
https://ncbi.nlm.nih.gov/pubmed/27693992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.09.003
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