Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine

Intestine is responsible for the biotransformation of many orally-exposed chemicals. The constitutive androstane receptor (CAR/Nr1i3) is known to up-regulate many genes encoding drug-metabolizing enzymes and transporters (drug-processing genes/DPGs) in liver, but less is known regarding its effect i...

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Bibliografiska uppgifter
I publikationen:Acta Pharm Sin B
Huvudupphovsmän: Park, Shinhee, Cheng, Sunny Lihua, Cui, Julia Yue
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2016
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045557/
https://ncbi.nlm.nih.gov/pubmed/27709017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2016.07.004
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