ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization

Most breast cancer deaths occur in women with recurrent, estrogen receptor (ER)-α(+), metastatic tumors. There is a critical need for therapeutic approaches that include novel, targetable mechanism-based strategies by which ERα (+) tumors can be resensitized to endocrine therapies. The objective of...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Endocrinol
Main Authors: Wrobel, Kinga, Zhao, Yiru Chen, Kulkoyluoglu, Eylem, Chen, Karen Lee Ann, Hieronymi, Kadriye, Holloway, Jamie, Li, Sarah, Ray, Tania, Ray, Partha Sarathi, Landesman, Yosef, Lipka, Alexander Edward, Smith, Rebecca Lee, Madak-Erdogan, Zeynep
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2016
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045498/
https://ncbi.nlm.nih.gov/pubmed/27533791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2016-1101
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