Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells

RNA Polymerase II Elongation Factor (ELL)-associated factor 2 (EAF2) is a tumor suppressor frequently down-regulated in human prostate cancer. We previously reported that its binding partner ELL1 can enhance EAF2 protein stability and activity. Here we show that EAF2 can be polyubiquitinated and its...

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Pubblicato in:Oncotarget
Autori principali: Yu, Xinpei, Ai, Junkui, Cai, Liquan, Jing, Yifeng, Wang, Dan, Dong, Jun, Pascal, Laura E., Zhang, Jian, Luo, Rongcheng, Wang, Zhou
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045393/
https://ncbi.nlm.nih.gov/pubmed/27058417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8588
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