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The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro

Organophosphates (OPs) are potentially able to affect serine proteases by reacting with their active site. The potential effects of OPs on coagulation factors such as thrombin and on coagulation tests have been only partially characterized and potential interactions with OPs antidotes such as oximes...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Golderman, Valery, Shavit-Stein, Efrat, Tamarin, Ilia, Rosman, Yossi, Shrot, Shai, Rosenberg, Nurit, Maggio, Nicola, Chapman, Joab, Eisenkraft, Arik
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045196/
https://ncbi.nlm.nih.gov/pubmed/27689805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163787
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