The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro

Organophosphates (OPs) are potentially able to affect serine proteases by reacting with their active site. The potential effects of OPs on coagulation factors such as thrombin and on coagulation tests have been only partially characterized and potential interactions with OPs antidotes such as oximes...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Golderman, Valery, Shavit-Stein, Efrat, Tamarin, Ilia, Rosman, Yossi, Shrot, Shai, Rosenberg, Nurit, Maggio, Nicola, Chapman, Joab, Eisenkraft, Arik
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045196/
https://ncbi.nlm.nih.gov/pubmed/27689805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163787
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