STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function

Mammalian CST (CTC1-STN1-TEN1) participates in multiple aspects of telomere replication and genome-wide recovery from replication stress. CST resembles Replication Protein A (RPA) in that it binds ssDNA and STN1 and TEN1 are structurally similar to RPA2 and RPA3. Conservation between CTC1 and RPA1 i...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Bhattacharjee, Anukana, Stewart, Jason, Chaiken, Mary, Price, Carolyn M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045167/
https://ncbi.nlm.nih.gov/pubmed/27690379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006342
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