Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System

Cell culture systems reproducing virus replication can serve as unique models for the discovery of novel bioactive molecules. Here, using a hepatitis C virus (HCV) cell culture system, we identified neoechinulin B (NeoB), a fungus-derived compound, as an inhibitor of the liver X receptor (LXR). NeoB...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Nakajima, Syo, Watashi, Koichi, Ohashi, Hirofumi, Kamisuki, Shinji, Izaguirre-Carbonell, Jesus, Kwon, Andrew Tae-Jun, Suzuki, Harukazu, Kataoka, Michiyo, Tsukuda, Senko, Okada, Maiko, Moi, Meng Ling, Takeuchi, Toshifumi, Arita, Minetaro, Suzuki, Ryosuke, Aizaki, Hideki, Kato, Takanobu, Suzuki, Tadaki, Hasegawa, Hideki, Takasaki, Tomohiko, Sugawara, Fumio, Wakita, Takaji
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044839/
https://ncbi.nlm.nih.gov/pubmed/27489280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00856-16
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