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Representing and decomposing genomic structural variants as balanced integer flows on sequence graphs

BACKGROUND: The study of genomic variation has provided key insights into the functional role of mutations. Predominantly, studies have focused on single nucleotide variants (SNV), which are relatively easy to detect and can be described with rich mathematical models. However, it has been observed t...

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Veröffentlicht in:BMC Bioinformatics
Hauptverfasser: Zerbino, Daniel R., Ballinger, Tracy, Paten, Benedict, Hickey, Glenn, Haussler, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043639/
https://ncbi.nlm.nih.gov/pubmed/27687569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1258-4
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