Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing

Alzheimer’s disease (AD) is the most prevalent form of dementia characterized by the extracellular accumulation of amyloid β (Aβ) peptides, which are produced by proteolytic cleavages of amyloid precursor protein (APP). Gangliosides are involved in AD pathophysiology including Aβ deposition and APP...

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Pubblicato in:Sci Rep
Autori principali: Yamaguchi, Tokiaki, Yamauchi, Yoshio, Furukawa, Keiko, Ohmi, Yuhsuke, Ohkawa, Yuki, Zhang, Qing, Okajima, Tetsuya, Furukawa, Koichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043288/
https://ncbi.nlm.nih.gov/pubmed/27687691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34505
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