Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing

Alzheimer’s disease (AD) is the most prevalent form of dementia characterized by the extracellular accumulation of amyloid β (Aβ) peptides, which are produced by proteolytic cleavages of amyloid precursor protein (APP). Gangliosides are involved in AD pathophysiology including Aβ deposition and APP...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yamaguchi, Tokiaki, Yamauchi, Yoshio, Furukawa, Keiko, Ohmi, Yuhsuke, Ohkawa, Yuki, Zhang, Qing, Okajima, Tetsuya, Furukawa, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043288/
https://ncbi.nlm.nih.gov/pubmed/27687691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34505
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