Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality

Targeted disruption of Cripto-1 in mice caused embryonic lethality at E7.5, whereas we unexpectedly found that ectopic Cripto-1 expression in mouse embryos also led to embryonic lethality, which prompted us to characterize the causes and mechanisms underlying embryonic death due to ectopic Cripto-1...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lin, Xiaolin, Zhao, Wentao, Jia, Junshuang, Lin, Taoyan, Xiao, Gaofang, Wang, Shengchun, Lin, Xia, Liu, Yu, Chen, Li, Qin, Yujuan, Li, Jing, Zhang, Tingting, Hao, Weichao, Chen, Bangzhu, Xie, Raoying, Cheng, Yushuang, Xu, Kang, Yao, Kaitai, Huang, Wenhua, Xiao, Dong, Sun, Yan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043281/
https://ncbi.nlm.nih.gov/pubmed/27687577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34501
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