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Lineage-specific and single cell chromatin accessibility charts human hematopoiesis and leukemia evolution
We define the chromatin accessibility and transcriptional landscapes in thirteen human primary blood cell types that traverse the hematopoietic hierarchy. Exploiting the finding that the enhancer landscape better reflects cell identity than mRNA levels, we enable “enhancer cytometry” for enumeration...
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| Publicado no: | Nat Genet |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5042844/ https://ncbi.nlm.nih.gov/pubmed/27526324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3646 |
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