Impact of quercetin-induced changes in drug-metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats

The aim of the present study was to evaluate whether quercetin (Que) modulates the mRNA and protein expression levels of drug-metabolizing enzymes (DMEs) and drug transporters (DTs) in the small intestine and liver, and thus modifies the pharmacokinetic profile of cyclosporine (CsA) in rats. This tw...

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Published in:Mol Med Rep
Main Authors: Liu, Yani, Luo, Xiaomei, Yang, Chunxiao, Yang, Tingyu, Zhou, Jiali, Shi, Shaojun
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042751/
https://ncbi.nlm.nih.gov/pubmed/27510982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2016.5616
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