Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages

Macrophages are key responders of inflammation and are closely related with oxidative stress. Activated macrophages can enhance oxygen depletion, which causes an overproduction of reactive oxygen species (ROS) and leads to further excessive inflammatory response and tissue damage. Agmatine, an endog...

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Vydáno v:PLoS One
Hlavní autoři: Chai, Jianshen, Luo, Li, Hou, Fengyan, Fan, Xia, Yu, Jing, Ma, Wei, Tang, Wangqi, Yang, Xue, Zhu, Junyu, Kang, Wenyuan, Yan, Jun, Liang, Huaping
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042521/
https://ncbi.nlm.nih.gov/pubmed/27685463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163634
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