Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages

Macrophages are key responders of inflammation and are closely related with oxidative stress. Activated macrophages can enhance oxygen depletion, which causes an overproduction of reactive oxygen species (ROS) and leads to further excessive inflammatory response and tissue damage. Agmatine, an endog...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chai, Jianshen, Luo, Li, Hou, Fengyan, Fan, Xia, Yu, Jing, Ma, Wei, Tang, Wangqi, Yang, Xue, Zhu, Junyu, Kang, Wenyuan, Yan, Jun, Liang, Huaping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042521/
https://ncbi.nlm.nih.gov/pubmed/27685463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163634
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