Potential protein targets of the peptidylarginine deiminase 2 and peptidylarginine deiminase 4 enzymes in rheumatoid synovial tissue and its possible meaning

OBJECTIVE: The molecular mechanism of citrullination involves the calcium-dependent peptidylarginine deiminase (PAD) family of enzymes. These enzymes induce a stereochemical modification of normal proteins and transform them into autoantigens, which in rheumatoid arthritis trigger a complex cascade...

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Detalhes bibliográficos
Publicado no:Eur J Rheumatol
Main Authors: Badillo-Soto, Martha Adriana, Rodríguez-Rodríguez, Mayra, Pérez-Pérez, María Elena, Daza-Benitez, Leonel, Bollain-y-Goytia, Juan José, Carrillo-Jiménez, Miguel Angel, Avalos-Díaz, Esperanza, Herrera-Esparza, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Medical Research and Education Association 2016
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042229/
https://ncbi.nlm.nih.gov/pubmed/27708970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5152/eurjrheum.2015.0055
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