Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death

Differentiation-inducing factor (DIF) defines a group of chlorinated hexaphenones that orchestrate stalk-cell differentiation in the slime mold Dictyostelium discoideum (DD). DIF-1 and 3 have also been reported to have tumor inhibiting properties; however, the mechanisms that underlie the effects of...

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Udgivet i:Oncotarget
Main Authors: Dubois, Alix, Ginet, Clemence, Furstoss, Nathan, Belaid, Amine, Hamouda, Mohamed Amine, El Manaa, Wedjene, Cluzeau, Thomas, Marchetti, Sandrine, Ricci, Jean Ehrland, Jacquel, Arnaud, Luciano, Frederic, Driowya, Mohsine, Benhida, Rachid, Auberger, Patrick, Robert, Guillaume
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041969/
https://ncbi.nlm.nih.gov/pubmed/27027430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8319
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