Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism

BACKGROUND: The cholinergic anti-inflammatory pathway (CAP) primarily functions through acetylcholine (ACh)-alpha7 nicotinic acetylcholine receptor (α7nAChR) interaction on macrophages to control peripheral inflammation. Interestingly, ACh can also bind α7nAChRs on microglia resulting in neuroprotec...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Revathikumar, Priya, Bergqvist, Filip, Gopalakrishnan, Srividya, Korotkova, Marina, Jakobsson, Per-Johan, Lampa, Jon, Le Maître, Erwan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041575/
https://ncbi.nlm.nih.gov/pubmed/27681882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0725-1
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