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Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning

Attenuation of ribosome biogenesis in suboptimal growth environments is crucial for cellular homeostasis and genetic integrity. Here, we show that shutdown of rRNA synthesis in response to elevated temperature is brought about by mechanisms that target both the RNA polymerase I (Pol I) transcription...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Zhao, Zhongliang, Dammert, Marcel A., Hoppe, Sven, Bierhoff, Holger, Grummt, Ingrid
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041454/
https://ncbi.nlm.nih.gov/pubmed/27257073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw496
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