Abnormal serum microRNA profiles in tuberous sclerosis are normalized during treatment with everolimus: possible clinical implications

BACKGROUND: Tuberous sclerosis (TSC) is a monogenic disease resulting from defects of the TSC1 or TSC2 genes, which encode the proteins forming hamartin-tuberin tumor suppressor complex, the mammalian target of rapamycin complex (mTOR). The mTOR pathway is constitutively activated in response to tub...

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Detalhes bibliográficos
Publicado no:Orphanet J Rare Dis
Main Authors: Trelinska, Joanna, Fendler, Wojciech, Dachowska, Iwona, Kotulska, Katarzyna, Jozwiak, Sergiusz, Antosik, Karolina, Gnys, Piotr, Borowiec, Maciej, Mlynarski, Wojciech
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041396/
https://ncbi.nlm.nih.gov/pubmed/27680012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-016-0512-1
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