Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress

The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. Cytosporone B (Csn-B), an agonist for Nur77, and Nur77 knockdown were adopted...

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Vydáno v:Sci Rep
Hlavní autoři: Gao, Huimin, Chen, Zhaoyu, Fu, Yongmei, Yang, Xiaoyan, Weng, Ruihui, Wang, Rui, Lu, Jianjun, Pan, Mengqiu, Jin, Kunlin, McElroy, Chris, Tang, Beisha, Xia, Ying, Wang, Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041156/
https://ncbi.nlm.nih.gov/pubmed/27679973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34403
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