Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress

The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. Cytosporone B (Csn-B), an agonist for Nur77, and Nur77 knockdown were adopted...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gao, Huimin, Chen, Zhaoyu, Fu, Yongmei, Yang, Xiaoyan, Weng, Ruihui, Wang, Rui, Lu, Jianjun, Pan, Mengqiu, Jin, Kunlin, McElroy, Chris, Tang, Beisha, Xia, Ying, Wang, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041156/
https://ncbi.nlm.nih.gov/pubmed/27679973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34403
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