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Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases

Lysophosphatidic acid (LPA), generated in the microenvironment of cancer cells, can drive the proliferation, invasion, and migration of cancer cells by activating G protein-coupled LPA receptors. Moreover, in cancer cells that have metastasized to bone, LPA signaling can promote osteolysis by induci...

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Publicat a:Healthcare (Basel)
Autors principals: McCarty, Mark F., DiNicolantonio, James
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041061/
https://ncbi.nlm.nih.gov/pubmed/27571113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/healthcare4030060
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