PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

While much research has examined the use of glucose and glutamine by tumor cells, many cancers instead prefer to metabolize fats. Despite the pervasiveness of this phenotype, knowledge of pathways that drive fatty acid oxidation (FAO) in cancer is limited. Prolyl hydroxylase domain proteins hydroxyl...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: German, Natalie J., Yoon, Haejin, Yusuf, Rushdia Z., Murphy, J. Patrick, Finley, Lydia W.S., Laurent, Gaëlle, Haas, Wilhelm, Satterstrom, F. Kyle, Guarnerio, Jlenia, Zaganjor, Elma, Santos, Daniel, Pandolfi, Pier Paolo, Beck, Andrew H., Gygi, Steven P., Scadden, David T., Kaelin, William G., Haigis, Marcia C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040345/
https://ncbi.nlm.nih.gov/pubmed/27635760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.014
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