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Overexpression of factor VIII after AAV delivery is transiently associated with cellular stress in hemophilia A mice
Factor VIII (FVIII) is a large glycoprotein that is challenging to express both in vitro and in vivo. Several studies suggest that high levels of FVIII expression can lead to cellular stress. After gene transfer, transgene expression is restricted to a subset of cells and the increased FVIII load pe...
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| Publicado no: | Mol Ther Methods Clin Dev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5040173/ https://ncbi.nlm.nih.gov/pubmed/27738645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.64 |
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