Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium

BACKGROUND: In response to tissue damage or inflammation, adenosine-5′-triphosphate (ATP) is released into the extracellular compartment and has been demonstrated to augment inflammation via purinergic P2 receptors (P2Rs). Recently, ATP has been shown to be increased in the airways of COPD patients....

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Shishikura, Yutaka, Koarai, Akira, Aizawa, Hiroyuki, Yamaya, Mutsuo, Sugiura, Hisatoshi, Watanabe, Mika, Hashimoto, Yuichiro, Numakura, Tadahisa, Makiguti, Tomonori, Abe, Kyoko, Yamada, Mituhiro, Kikuchi, Toshiaki, Hoshikawa, Yasushi, Okada, Yoshinori, Ichinose, Masakazu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039824/
https://ncbi.nlm.nih.gov/pubmed/27677339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0438-0
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