High Stoichiometry Phosphorylation of Talin at T144/T150 or S446 Produces Contrasting Effects on Calpain-mediated Talin Cleavage and Cell Migration

Focal adhesions are large multi-protein complexes that serve as the linkage between extracellular matrix (ECM) and actin cytoskeleton and control the network of signaling cascades underlying cell migration. Talin plays a key role in focal adhesion turnover, and calpain-mediated proteolysis of talin...

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Bibliographic Details
Published in:J Cancer
Main Authors: Li, Youjun, Luo, Xiaoyong, Sun, Yang, Cui, Zhenyi, Liu, Yizhou, Liu, Rushi, Guo, Xiangrong
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039385/
https://ncbi.nlm.nih.gov/pubmed/27698901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.14192
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