A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

Mutations of mtDNA are an important cause of human disease, but few animal models exist. Because mammalian mitochondria cannot be transfected, the development of mice with pathogenic mtDNA mutations has been challenging, and the main strategy has therefore been to introduce mutations found in cell l...

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Pubblicato in:Cell Rep
Autori principali: Kauppila, Johanna H.K., Baines, Holly L., Bratic, Ana, Simard, Marie-Lune, Freyer, Christoph, Mourier, Arnaud, Stamp, Craig, Filograna, Roberta, Larsson, Nils-Göran, Greaves, Laura C., Stewart, James B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039181/
https://ncbi.nlm.nih.gov/pubmed/27626666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.037
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