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Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing
Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses’ silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5039111/ https://ncbi.nlm.nih.gov/pubmed/27662090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.006 |
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