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Comparative Characterization of CTX-M-64 and CTX-M-14 Provides Insights into the Structure and Catalytic Activity of the CTX-M Class of Enzymes

Clinical isolates producing hybrid CTX-M β-lactamases, presumably due to recombination between the bla(CTX-M-15) and bla(CTX-M-14) elements, have emerged in recent years. Among the hybrid enzymes, CTX-M-64 and CTX-M-14 display the most significant difference in catalytic activity. This study aims to...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: He, Dandan, Chiou, Jiachi, Zeng, Zhenling, Chan, Edward Wai-Chi, Liu, Jian-Hua, Chen, Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038261/
https://ncbi.nlm.nih.gov/pubmed/27480856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00917-16
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